Measuring neuronal activity with electrophysiological methods may be useful in detecting neurological dysfunctions, such as mild traumatic brain injury (mTBI). This approach may be particularly valuable for rapid detection in at-risk populations including military service members and athletes. Electrophysiological methods, such as quantitative electroencephalography (qEEG) and recording event-related potentials (ERPs) may be promising; however, the field is nascent and significant controversy exists on the efficacy and accuracy of the approaches as diagnostic tools. For example, the specific measures derived from an (...) electroencephalogram (EEG) that are most suitable as markers of dysfunction have not been clearly established. A study was conducted to summarize and evaluate the statistical rigor of evidence on the overall utility of qEEG as an mTBI detection tool. The analysis evaluated qEEG measures/parameters that may be most suitable as fieldable diagnostic tools, identified other types of EEG measures and analysis methods of promise, recommended specific measures and analysis methods for further development as mTBI detection tools, identified research gaps in the field, and recommended future research and development thrust areas. The qEEG study group formed the following conclusions: 1. Individual qEEG measures provide limited diagnostic utility for mTBI. However, many measures can be important features of qEEG discriminant functions, which do show significant promise as mTBI detection tools. 2. ERPs offer utility in mTBI detection. In fact, evidence indicates that ERPs can identify abnormalities in cases where EEGs alone are nondisclosing. 3. The standard mathematical procedures used in the characterization of mTBI EEGs should be expanded to incorporate newer methods of analysis including nonlinear dynamical analysis, complexity measures, analysis of causal interactions, graph theory and information dynamics. 4. and 5. are too long to include here. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Beyond Realism & Anti-Realism: John Dewey and the NeopragmatistsAndrew W. HowatDavid L. Hildebrand Beyond Realism & Anti-Realism: John Dewey and the Neopragmatists Nashville: Vanderbilt University Press, 2003. xii + 241 pp.In this book David Hildebrand provides a spirited defence of the philosophy of John Dewey, a defence he claims is faithful to his actual views and contrary to those of the "neopragmatists," specifically Hilary Putnam (...) and Richard Rorty. Hildebrand rejects the neopragmatist assumption that Dewey's oeuvre can support one or other side of the realism/anti-realism debate, at least without obscuring some of Dewey's vital insights. In particular, he thinks Rorty and Putnam miss the centrality and significance of Dewey's "Practical Starting Point" for philosophy and his understanding of key concepts such as "knowledge," "experience" and "inquiry." He argues that when taken together these insights show that Dewey transcends traditional debates about realism, and that this was the essence of his pragmatism.The first two chapters set out Dewey's views in the context of his contemporaries (especially the New and Critical Realists). They emphasise the radical nature of Dewey's position; that it aimed to supplant the well-established philosophical dualisms and debates of the day. Chapters Three and Four recount and criticise how Rorty and Putnam employ Dewey's insights to support near-opposite ends of the realism/anti-realism debate. The final chapter summarises and recapitulates the central themes and arguments of the book.Hildebrand describes his motivating worries as "pedagogical" and "political." If contemporary pragmatists serve as authorities on the subject, [End Page 296] this threatens to occlude the significance of classical texts for new students. This would be unfortunate, as those original texts are beautiful pieces of philosophy. Moreover, there is the danger that contemporary 'authorities' on pragmatism are mistaken, or have their own distorting agenda. It is thus vital that students and professionals continue to study original texts, gaining a grasp on this subtle and rewarding era of philosophy first-hand.Hildebrand's argument is immediately plausible, given that misinterpretations and caricatures of classical pragmatism are sadly common and familiar. It is also novel however, as it asserts pragmatism's foremost contemporary representatives are also guilty of misinterpretation. Hildebrand courts controversy, concluding his introduction by saying the neopragmatists "misuse central epistemological and metaphysical views of classical pragmatism for their own ends, all the while sustaining dualisms that the classical pragmatists fought to dissolve." This book may polarise opinion about Hildebrand's success, if so contemporary debate about pragmatism should be enriched.Readers may enjoy the novel account of New and Critical Realism in Chapter One, movements of which I knew nothing before reading the book. Hildebrand uses these movements to locate Dewey historically and dialectically amid the popular realism & idealism of his time. He demonstrates Dewey's views clearly diverged from those of his contemporaries, despite some of their best efforts to assimilate them for their realist or idealist cause. His main argument concerns Dewey's view that New Realists were responsible for hypostatising the faculties of knowledge and perception and conflating their products, resulting in paradoxical psychophysical dualism. They claimed that knowledge "can be simply had, in an instant," while Dewey insisted that "knowledge is an achievement, the eventual, alembicated product of inquiry," and that contrary to the way New Realists made it sound "Knowledge is never received like manna from heaven." Dewey's work on the reflex arc illustrated that perception is similarly an active or participatory process, though its products are distinct from those of knowledge. Hildebrand argues Dewey was trying to show how such mistakes created two crippling problems for New Realism: the problem of illusion and relapse into the very idealism the movement was designed to refute.Chapter Two concerns aspects of Dewey's views which realists (New and Critical) considered at odds with their own, implying too close an affinity with idealism. Like its predecessor this chapter would benefit from more (or better) examples to help elucidate Dewey's sometimes oblique prose. The dialectic is often highly abstract, focusing on such notions as the given (versus Dewey's preferred "taken"), Dewey's unusual understanding of temporal epistemology (knowledge of past... (shrink)

Loneliness in medicine is a serious problem not just for patients, for whom illness is intrinsically isolating, but also for physicians in the contemporary condition of medicine. We explore this problem by investigating the ideal physician-patient relationship, whose analogy with friendship has held enduring normative appeal. Drawing from Talbot Brewer and Nir Ben-Moshe, we argue that this appeal lies in a dynamic form of companionship incompatible with static models of friendship-like physician-patient relationships: a mutual refinement of embodied virtue that draws (...) both persons together. The ideal physician-patient relationship has a dialectical character that fosters each member's improvement of phenomenologically recognizing and embodying moral virtues. A key component of this dynamic is a commitment to the common goal of the patient's health, realized through joint interactivities and conversations over time. The physician's presence to the patient's suffering—understood best as an alienating phenomenological condition for the patient—orients and discloses possibilities for virtuous caregiving by structuring the meanings of the goals, conversations, and joint narrative constitutive of their relationship. Presence to suffering, paradoxically, is perhaps an important prerequisite for this dynamic partnership. These activities dialectically build an interpretive horizon of understanding through which moral goods and character refinement—in and for the other—may become revealed for both persons in their shared being-in-the-world. This analysis of suffering, mood, and revealing of (possible) moral goods has implications for addressing the modern problem of loneliness for patients and physicians, who are increasingly inhibited from building flourishing relationships with each other. (shrink)

In a fair, infinite lottery, it is possible to conclude that drawing a number divisible by four is strictly less likely than drawing an even number; and, with apparently equal cogency, that drawing a number divisible by four is equally as likely as drawing an even number.

Galileo's refutation of the speed-distance law of fall in his Two New Sciences is routinely dismissed as a moment of confused argumentation. We urge that Galileo's argument correctly identified why the speed-distance law is untenable, failing only in its very last step. Using an ingenious combination of scaling and self-similarity arguments, Galileo found correctly that bodies, falling from rest according to this law, fall all distances in equal times. What he failed to recognize in the last step is that this (...) time is infinite, the result of an exponential dependence of distance on time. Instead, Galileo conflated it with the other motion that satisfies this ‘equal time’ property, instantaneous motion. (shrink)

In this reply, we respond to the comments of Palmerino and Laird on our article, "Galileo's Refutation of the Speed Distance Law of Fall Rehabilitated," published in the same issue of Centaurus.

We suggest that in the particular context of medical education, ethics can be considered in a similar way to other kinds of knowledge that are categorised and shaped by academics in the context of wider society. Moreover, the study of medical ethics education is translational in a manner loosely analogous to the study of medical education as adjunct to translational medicine. Some have suggested there is merit in the idea that much as translational research attempts to connect the laboratory scientist's (...) work to its implications for patient care, translational ethics focuses on bringing ethics scholarship into the sphere of personal and public action. We distinguish the term ‘translational ethics’ (the study of ethics being translated between academy, classroom and clinic) from other prominent definitions in the bioethics literature. To do this, we build off a notion of knowledge translation that focuses on the nonlinear movement of information that comes to professionals through multiple competing sources. We suggest that this knowledge, and particularly knowledge about ethics, becomes embodied by the individual. It is through a reflective practice that internally embedded ethics knowledge might be modified, and this work might be best carried out with a moral community that maintains a sense of practical wisdom. Applying this translational approach to the study of medical ethics education can be both academically relevant and practically useful. This view of translation can help bridge the evident, multidirectional relationships between research, education and performance. It might also create further opportunities to develop medical ethics education theory. (shrink)

In this paper, we examine whether ethics officers are able to perform their assigned duties independently of organizational management. Specifically, we investigate whether inherent conflicts of interest with company management potentially hinder the ability of ethics officers to serve as an effective monitor and deterrent of unethical activity throughout the organization. As part of our analysis, we conducted 10 detailed phone interviews with current and retired ethics officers in order to determine whether practicing ethics officers feel the need for additional (...) independence protection from management. We propose that the current system in which ethics officers report to management must be changed in order for ethics officers to effectively perform their jobs. Specifically, we maintain that ethics officers should (1) be hired by, (2) be fired by, and (3) report directly to the corporate board of directors rather than company management. Such a change in the reporting environment would greatly enhance the independence of ethics officers. (shrink)

Antonio Gramsci is one of the major social and political theorists of the 20th century whose work has had an enormous influence on several fields, including educational theory and practice. Gramsci and Education demonstrates the relevance of Antonio Gramsci's thought for contemporary educational debates. The essays are written by scholars located in different parts of the world, a number of whom are well known internationally for their contributions to Gramscian scholarship and/or educational research. The collection deals with a broad range (...) of topics, including schooling, adult education in general, popular education, workers' education, cultural studies, critical pedagogy, multicultural education, and the role of intellectuals in contemporary society. (shrink)

Working Memory plays a crucial role in many high-level cognitive processes . The prevalent view holds that active components of WM are predominantly intentional and conscious. This conception is oftentimes expressed explicitly, but it is best reflected in the nature of major WM tasks: All of them are blatantly explicit. We developed two new WM paradigms that allow for an examination of the role of conscious awareness in WM. Results from five studies show that WM can operate unintentionally and outside (...) of conscious awareness, thus suggesting that the current view should be expanded to include implicit WM. (shrink)

iinstein oered the prin™iple of gener—l ™ov—ri—n™e —s the fund—ment—l physi™—l prin™iple of his gener—l theory of rel—tivityD —nd —s responsi˜le for extending the prin™iple of rel—tivity to —™™eler—ted motionF „his view w—s disputed —lmost immedi—tely with the ™ounterE™l—im th—t the prin™iple w—s no rel—tivity prin™iple —nd w—s physi™—lly v—™uousF „he dis—greeE ment persists tod—yF „his —rti™le reviews the development of iinstein9s thought on gener—l ™ov—ri—n™eD its rel—tion to the found—tions of gener—l rel—tivity —nd the evolution of the ™ontinuing de˜—te (...) over his viewpointF.. (shrink)

Events and intellectual fashion have conspired to bring the once neglected topics of nationalism and Staatslehre to the forefront of political-philosophical debate in this country, a development which makes David Runciman’s intellectual-historical study quite timely. The history Runciman tells is that of the early twentieth century English movement of political pluralism, whose central figures were Frederic W. Maitland, John N. Figgis, Ernest Barker, George D. H. Cole, and Harold Laski. To tell their story Runciman quite properly recognizes that he (...) must also discuss Thomas Hobbes and Otto von Gierke. For the story of political pluralism is the story of a debate over the concept of group personality, the problems of which are originally and decisively formulated by Hobbes, but which are received by the English pluralists by way of Gierke. Runciman’s approach here is “somewhat dialectical”, in that the discussions of Hobbes and Gierke are meant to shed light upon the English pluralists even as the discussions of the latter are intended to illuminate them. Runciman characterizes this as a movement between philosophy and history. (shrink)

We submit this brief in support of the Nonhuman Rights Project’s efforts to secure habeas corpus relief for the elephant named Happy. We reject arbitrary distinctions that deny adequate protections to other animals who share with protected humans relevantly similar vulnerabilities to harms and relevantly similar interests in avoiding such harms. We strongly urge this Court, in keeping with the best philosophical standards of rational judgment and ethical standards of justice, to recognize that, as a nonhuman person, Happy should be (...) released from her current confinement and transferred to an appropriate elephant sanctuary, pursuant to habeas corpus. (shrink)

Medical-legal partnerships connect legal advocates to healthcare providers and settings. Maintaining effectiveness of medical-legal partnerships and consistently identifying opportunities for innovation and adaptation takes intentionality and effort. In this paper, we discuss ways in which our use of data and quality improvement methods have facilitated advocacy at both patient (client) and population levels as we collectively pursue better, more equitable outcomes.